Napyradiomycins A and B1: non-steroidal estrogen-receptor antagonists produced by a Streptomyces.
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چکیده
منابع مشابه
Napyradiomycins A and B1: non-steroidal estrogen-receptor antagonists produced by a Streptomyces.
Estrogen-receptor antagonists are used in the therapy of estrogen-responsive diseases including breast cancer and endometrial cancer. Tamoxifen, the non-steroidal estrogen-receptor antagonist, is now the first choice of anti-hormonal treatment for advanced breast cancer. In spite of its effectiveness, the long-term use of tamoxifen frequently results in tumor resistance to itself and its relate...
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The existence of two rather than one estrogen receptor, today characterized as estrogen receptor a (ERa) and estrogen receptor b (ERb), indicates that the mechanism of action of 17b-estradiol and related synthetic drugs is more complex than previously thought. Because the homology of amino acid residues in the ligand-binding domain (LBD) of ERb is high compared with those amino acid residues in...
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Objective(s): To address the alarming problem of methicillin-resistant Staphylococcus aureus (MRSA), herein, a marine Streptomyces capable of producing an anti-MRSA compound has been studied.Materials and Methods: Strain MN41 was morphologically and physiologically characterized and then, molecularly identified using 16SrRNA analysis. To...
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Twelve novel β-lactams were synthesized and their antiproliferative effects and binding affinity for the predominant isoforms of the estrogen receptor (ER), ERα and ERβ, were determined. β-Lactams 23 and 26 had the strongest binding affinities for ERα (IC50 values: 40 and 8 nM, respectively) and ERβ (IC50 values: 19 and 15 nM). β-Lactam 26 was the most potent in antiproliferative assays using M...
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Triclosan is an antibacterial agent commonly used in industry and often detected in waste-water effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bisphenol A). Japanese medaka fry (Oryzias latipes) were exposed for 14 days beginning 2 days post-hatch to triclosan (100, 10, ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1993
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.46.1890